Ammonium Hydroxide → HCID 178418808、化合物

HRID 586779

反応式

HRID 586779 の反応式
[CH2:1]([S:7][S:8][CH2:9][C@H:10]([NH2:14])[C:11]([OH:13])=[O:12])[C@H:2]([NH2:6])[C:3]([OH:5])=[O:4].S(O)(O)(=O)=O.CO[C:22](=[NH:24])[NH2:23].[OH-].[NH4+:26]>>[NH:23]([CH:1]([S:7][S:8][CH2:9][C@H:10]([NH2:14])[C:11]([OH:13])=[O:12])[C@H:2]([NH2:6])[C:3]([OH:5])=[O:4])[C:22]([NH2:24])=[NH:26]

参加物

4

反応物 3

HCID 14923Ammonium HydroxideHCID 67678(-)-CystineHCID 169039Carbamimidic acid, methyl ester, sulfate (1:1)

生成物 1

HCID 178418808HCID 178418808、化合物

反応条件

温度
60 °C

実験手順

To a solution of cystine (1 gm, 4.2 mmol) in ammonium hydroxide (10 mL) in a screw-capped vial was added O-methylisourea hydrogen sulfate (1.8 gm, 10 mmol). The vial was sealed and heated to 60° C. for 16 h. The solution was then cooled and the ammonium hydroxide was removed by rotary evaporation. The solid was then dissolved in water (20 mL), filtered through a cotton plug. The product was then isolated by ion exchange chromatography using Bio-Rex 70 resin and eluting with hydrochloric acid (100 mM).

後処理

  1. customThe vial was sealed
  2. temperatureThe solution was then cooled
  3. customthe ammonium hydroxide was removed by rotary evaporation
  4. dissolutionThe solid was then dissolved in water (20 mL)
  5. filtrationfiltered through a cotton plug
  6. customThe product was then isolated by ion exchange chromatography
  7. washeluting with hydrochloric acid (100 mM)

出典と根拠

ORDレコード
ord-f766fc4bf6e44144bf48a6254ad741d1
出典データセット
uspto-grants-2005_08
特許番号
US06936729B2

関連ノート

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