Water → 5-fluoropyridine-2-carboxylic Acid
反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:8])=[N:6][CH:7]=1.[Mn]([O-])(=O)(=O)=[O:10].[K+].[OH2:15]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:10])=[O:15])=[N:6][CH:7]=1参加物
4
実験手順
To water (100 ml) were added 5-fluoro-2-methylpyridine (J. Med. Chem., 32, 1970(1989): 2.2 g, 20 mmol) and potassium permanganate (19.1 g, 120 mmol), and heated under reflux for 4 hours. The reaction mixture was filtrated and the filtrate was concentrated, acidified with KHSO4, extracted with ethyl acetate and the extract was dried over Na2SO4. The solvent was evaporated to give the title compound (0.80 g; 28%).
後処理
- temperatureheated
- temperatureunder reflux for 4 hours
- filtrationThe reaction mixture was filtrated
- concentrationthe filtrate was concentrated
- extractionextracted with ethyl acetate
- dry with materialthe extract was dried over Na2SO4
- customThe solvent was evaporated
出典と根拠
- ORDレコード
- ord-0679ce60ed2046d98a2dfdf025d884e4
- 出典データセット
- uspto-grants-2005_08
- 特許番号
- US06936736B2
反応ノート
読み込み中…