Hydrochloric Acid → 2-(2-Methyl-1,3-dioxolan-2-yl)acetic acid

HRID 587027ノート

反応式

HRID 587027 の反応式
[CH3:1][C:2]1([CH2:7][C:8]([O:10]CC)=[O:9])[O:6][CH2:5][CH2:4][O:3]1.[OH-].[Na+].Cl>CO>[CH3:1][C:2]1([CH2:7][C:8]([OH:10])=[O:9])[O:6][CH2:5][CH2:4][O:3]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 80865Ethyl acetoacetate ethyleneglycol ketal

生成物 1

HCID 5600442-(2-Methyl-1,3-dioxolan-2-yl)acetic acid収率 97.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of ethyl 2-methyldioxolan-2-ylacetate (2.0 g) in methanol (69 ml) was added 1N sodium hydroxide solution (23 ml), and the mixture was stirred at room temperature overnight. Then, the mixture was neutralized with 1N hydrochloric acid, and the solvent was evaporated under reduced pressure. To the mixture was added ethyl acetate, and the mixture was dried with magnesium sulfate. The solvent was evaporated under reduced pressure to give 2-methyldioxolan-2-ylacetic acid (1.63 g) as colorless

後処理

  1. customthe solvent was evaporated under reduced pressure
  2. additionTo the mixture was added ethyl acetate
  3. dry with materialthe mixture was dried with magnesium sulfate
  4. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-39d1a3e036c64798b046a20b7c1fecd1
出典データセット
uspto-grants-2005_08
特許番号
US06936602B1

反応ノート

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