2,4-Dichloro-1,3,5-triazine → 2-[3-((4-Chloro-1,3,5-triazin-2-yl)amino)phenyl]ethanesulfonamide

HRID 587139

反応式

HRID 587139 の反応式
[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:10]=[C:11]([CH2:15]S(N)(=O)=O)[CH:12]=[CH:13][CH:14]=2)[N:3]=1.ClC1N=C(Cl)N=CN=1.NC1C=C(C[CH2:36][S:37]([NH2:40])(=[O:39])=[O:38])C=CC=1>>[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:10]=[C:11]([CH2:15][CH2:36][S:37]([NH2:40])(=[O:39])=[O:38])[CH:12]=[CH:13][CH:14]=2)[N:3]=1

参加物

4

反応物 3

HCID 178102,4-Dichloro-1,3,5-triazineHCID 582368712-(3-Aminophenyl)ethanesulfonamideHCID 866798223-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

生成物 1

HCID 866798252-[3-((4-Chloro-1,3,5-triazin-2-yl)amino)phenyl]ethanesulfonamide

実験手順

A4 was prepared following the general procedure reported for A1 using 2,4-dichloro-1,3,5-triazine and 2-(3-aminophenyl)ethanesulfonamide A3 as reacting agents. The crude product was purified by flash chromatography on silica gel (DCM/MeOH=100:0 to 4:1) to yield the desired product A5 (54%, 65% purity) as a brown solid. MS (ES) C11H12ClN5O2S requires: 313. found: 314 (M+H)+.

後処理

  1. customThe crude product was purified by flash chromatography on silica gel (DCM/MeOH=100:0 to 4:1)

出典と根拠

ORDレコード
ord-a16ce3a469d94f82bcc1535f4de70e87
出典データセット
uspto-grants-2016_01
特許番号
US09226929B2

関連ノート

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