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2,4-Dichloro-1,3,5-triazine → 2-[3-((4-Chloro-1,3,5-triazin-2-yl)amino)phenyl]ethanesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,4-Dichloro-1,3,5-triazine | HCID 17810 | — |
| 反応物 | 2-(3-Aminophenyl)ethanesulfonamide | HCID 58236871 | — |
| 反応物 | 3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide | HCID 86679822 | — |
| 生成物 | 2-[3-((4-Chloro-1,3,5-triazin-2-yl)amino)phenyl]ethanesulfonamide | HCID 86679825 | — |
反応手順
A4 was prepared following the general procedure reported for A1 using 2,4-dichloro-1,3,5-triazine and 2-(3-aminophenyl)ethanesulfonamide A3 as reacting agents. The crude product was purified by flash chromatography on silica gel (DCM/MeOH=100:0 to 4:1) to yield the desired product A5 (54%, 65% purity) as a brown solid. MS (ES) C11H12ClN5O2S requires: 313. found: 314 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09226929B2 |
| 出典データセット | uspto-grants-2016_01 |
| ORD ID | ord-a16ce3a469d94f82bcc1535f4de70e87 |
| 出典メモ | uspto-grants-2016_01 |