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HRID 587141作成日：2026年10月25日

2-(Methoxymethyl)piperidine hydrochloride → rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide

https://huagongshe.com/reaction/587141

反応式

関与物質

役割名称HCID仕込み量
反応物2-(Methoxymethyl)piperidine hydrochlorideHCID 45926159—
反応物3-[(4-(4,4-Difluoropiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamideHCID 60197102—
反応物3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamideHCID 86679822—
生成物rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamideHCID 60197106—

反応手順

B4 was prepared following the procedure reported for B2 using A1 and rac-2-methoxymethylpiperidine hydrochloride. The title compound was purified by thick-layer chromatography (silica gel, chloroform/MeOH 19:1) and obtained as a white crystalline solid; yield: 235 mg (67%). MS (ES) C17H24N6O3S requires: 392. found: 393 (M+H)+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09226929B2
出典データセットuspto-grants-2016_01
ORD IDord-db7379088f3d4dcca8d5b74f80ebf560
出典メモuspto-grants-2016_01