2-Benzylpyrrolidine → 3-[(4-(2-Benzylpyrrolidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide

HRID 587159

反応式

HRID 587159 の反応式
COCC1CCCCN1C1N=CN=C(NC2C=C(CS(N)(=O)=O)C=CC=2)N=1.Cl[C:29]1[N:34]=[CH:33][N:32]=[C:31]([NH:35][C:36]2[CH:37]=[C:38]([CH2:42][S:43]([NH2:46])(=[O:45])=[O:44])[CH:39]=[CH:40][CH:41]=2)[N:30]=1.[CH2:47]([CH:54]1[CH2:58][CH2:57][CH2:56][NH:55]1)[C:48]1[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=1>>[CH2:47]([CH:54]1[CH2:58][CH2:57][CH2:56][N:55]1[C:29]1[N:34]=[CH:33][N:32]=[C:31]([NH:35][C:36]2[CH:37]=[C:38]([CH2:42][S:43]([NH2:46])(=[O:45])=[O:44])[CH:39]=[CH:40][CH:41]=2)[N:30]=1)[C:48]1[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=1

参加物

4

反応物 3

HCID 3395562-BenzylpyrrolidineHCID 60197106rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamideHCID 866798223-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

生成物 1

HCID 601974073-[(4-(2-Benzylpyrrolidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide

実験手順

B26 was prepared following the procedure reported for B4 using A1 and rac-2-benzylpyrrolidine. It was obtained as a white crystalline solid; yield: 160 mg (42%). 1H NMR (300 MHz, d6-DMSO, 300K) δ 1.67-1.92 (m, 4H), 2.57-2.77 (m, 1H), 3.03-3.21 (m, 1H), 3.42-3.62 (m, 2H), 4.20 (2 s, 2H), 4.28-4.48 (m, 1H), 6.88 (bs, 2H), 6.93-7.08 (m, 1H), 7.12-7.38 (m, 6H), 7.58 and 7.71 (2 m, 1H), 7.82-8.01 (m, 1H), 8.23 and 8.30 (2 s, 1H), 9.66 (bs, 1H). MS (ES) C21H24N6O2S requires: 424. found: 425 (M+H)+.

後処理

  1. customB26 was prepared
  2. customIt was obtained as a white crystalline solid

出典と根拠

ORDレコード
ord-19706696b23d4ebaaa621b9c708286c8
出典データセット
uspto-grants-2016_01
特許番号
US09226929B2

関連ノート

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