N-benzyl-N-methyl-3-nitropyridin-2-amine → 2-N-methylpyridine-2,3-diamine
反応式
[CH2:1]([N:8](C)[C:9]1[C:14]([N+:15]([O-])=O)=[CH:13][CH:12]=[CH:11][N:10]=1)C1C=CC=CC=1>CCO.[Pd]>[CH3:1][NH:8][C:9]1[C:14]([NH2:15])=[CH:13][CH:12]=[CH:11][N:10]=1参加物
4
実験手順
A mixture of N-benzyl-N-methyl-3-nitropyridin-2-amine (15 g) and 10% Pd—C (6.56 g) in EtOH (300 mL) was hydrogenated under balloon pressure at room temperature over weekend. The catalyst was removed by filtration and the filtrate was concentrated in vacuo to give N2-methylpyridine-2,3-diamine (7.00 g) as a tan solid.
後処理
- waitwas hydrogenated under balloon pressure at room temperature over weekend
- customThe catalyst was removed by filtration
- concentrationthe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-3cb753d45eac47a4b4ed75133c0e2952
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09226921B2
反応ノート
読み込み中…