1,1'-Carbonyldiimidazole → HCID 118324853、化合物

反応式

[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][C@@H:4]([CH2:12][CH2:13][C:14]([OH:16])=O)[CH2:3]1.C1N=CN(C(N2C=NC=C2)=O)C=1.[F:29][C:30]1[C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[C:33]([C@H:40]([NH2:42])[CH3:41])=[CH:32][CH:31]=1>CN(C=O)C>[F:29][C:30]1[C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[C:33]([C@H:40]([NH:42][C:14](=[O:16])[CH2:13][CH2:12][C@@H:4]2[CH2:3][C:2](=[O:1])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[CH2:5]2)[CH3:41])=[CH:32][CH:31]=1

参加物

実験手順

To the stirred solution of (R)-3-(4-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)propanoic acid (0.8 g, 3.67 mmol) (Crude) in dry DMF (15 mL), CDI (0.713 g, 4.40 mmol) was added. The reaction mixture was stirred at RT for 0.5 h. Then (R)-1-(4-fluoronaphthalen-1-yl)ethanamine (0.832 g, 4.40 mmol) was added and the reaction mixture was stirred at RT for 2 h. After completion of reaction ice was added to reaction mixture, solid precipitated out was filtered through Buchner funnel to get title compound (830 mg, 58.1%); m/z 390.54. Crude was taken without purification for next reaction.