HCID 117608159、化合物 → HCID 117608156、化合物
反応式
[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH2:14][CH:15]([CH2:20][C:21]#[N:22])[C:16]([O:18][CH3:19])=[O:17])[C:10]([O:12][CH3:13])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]>CC(O)=O.[Pd]>[NH2:22][CH2:21][CH2:20][CH:15]([CH2:14][C@H:9]([NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[C:10]([O:12][CH3:13])=[O:11])[C:16]([O:18][CH3:19])=[O:17]参加物
4
実験手順
To a solution of (2S)-dimethyl 2-((tert-butoxycarbonyl)amino)-4-(cyanomethyl)pentanedioate (10.0 g, 31.8 mmol) in AcOH (240 mL) was added 10% Pd/C (2.0 g) and the mixture was stirred under H2 atmosphere (70 psi) for 3 h. The mixture was filtered through a pad of Celite and the filtrate was evaporated under reduced pressure. The residue was treated with MTBE and evaporated again to afford (4S)-dimethyl 2-(2-aminoethyl)-4-((tert-butoxycarbonyl)amino)pentanedioate (crude) as a light pink solid.