Azetidine → 4-(Azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (2-dimethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-amide

HRID 588446ノート

反応式

HRID 588446 の反応式
[NH:1]1[CH2:4][CH2:3][CH2:2]1.[CH3:5][N:6]([CH3:28])[C:7]1[N:27]=[C:10]2[CH:11]=[CH:12][C:13]([NH:15][C:16]([C:18]3[N:22]([CH3:23])[N:21]=[CH:20][C:19]=3[C:24](O)=[O:25])=[O:17])=[CH:14][N:9]2[N:8]=1>>[CH3:5][N:6]([CH3:28])[C:7]1[N:27]=[C:10]2[CH:11]=[CH:12][C:13]([NH:15][C:16]([C:18]3[N:22]([CH3:23])[N:21]=[CH:20][C:19]=3[C:24]([N:1]3[CH2:4][CH2:3][CH2:2]3)=[O:25])=[O:17])=[CH:14][N:9]2[N:8]=1

参加物

3

反応物 2

HCID 10422AzetidineHCID 894640535-(2-Dimethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid

生成物 1

HCID 715384184-(Azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (2-dimethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-amide

実験手順

Using azetidine and 5-(2-dimethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid, the title compound was prepared in the same manner as described for example 2. Brown solid (93 mg, 42%). MS: m/z=369 (M+H+). Ames test negative.

出典と根拠

ORDレコード
ord-aada900734a54cdf8c012d9557a4f5c7
出典データセット
uspto-grants-2016_01
特許番号
US09227970B2

反応ノート

読み込み中…