Hydrochloric Acid → Benzyl 2-(1-aminoethyl)thiazole-5-carboxylate hydrochloride
反応式
C(OC([NH:8][CH:9]([C:11]1[S:12][C:13]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])=[CH:14][N:15]=1)[CH3:10])=O)(C)(C)C.[ClH:26]>C1COCC1.O1CCOCC1>[ClH:26].[NH2:8][CH:9]([C:11]1[S:12][C:13]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])=[CH:14][N:15]=1)[CH3:10]参加物
5
実験手順
To a solution of benzyl 2-(1-(tert-butoxycarbonylamino)ethyl)thiazole-5-carboxylate (0.55 g, 0.55 mmol) in THF (2 mL) was added 4M HCl in dioxane (0.5 ml). The reaction solution was stirred at room temperature overnight. The solution was concentrated to dryness to afford a colorless oil (0.45 g, 100%). LC-MS: (FA) ES+ 263.
後処理
- concentrationThe solution was concentrated to dryness
出典と根拠
- ORDレコード
- ord-ca0ae3fa22344cdf846acc52859dd646
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09227951B2
反応ノート
読み込み中…