HCID 117690809、化合物 → HCID 80702525、化合物
反応式
[OH:1][C:2]1([CH3:19])[CH2:7][CH2:6][N:5]([CH2:8][C:9]([O:11]CC2C=CC=CC=2)=[O:10])[CH2:4][CH2:3]1>CO.[Pd]>[OH:1][C:2]1([CH3:19])[CH2:3][CH2:4][N:5]([CH2:8][C:9]([OH:11])=[O:10])[CH2:6][CH2:7]1参加物
4
実験手順
To a solution of compound benzyl 2-(4-hydroxy-4-methylpiperidin-1-yl)acetate (400 mg, 1.61 mmol) in methanol (10 mL) was added Pd/C (10%, 100 mg) and the mixture was stirred under hydrogen atmosphere at ambient temperature for 1 h. The mixture was filtered through a pad of Celite and the filtrate was concentrated to afford 2-(4-hydroxy-4-methylpiperidin-1-yl)acetic acid (250 mg, quantitative) as a colorless solid, which was used directly without further purification.
後処理
- filtrationThe mixture was filtered through a pad of Celite
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-fda24af28cdb4dd9aac9e017fdcb4adc
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434761B2
反応ノート
読み込み中…