Methyl iodide → 1-methyl-2-(methylsulfanyl)-4,5-dihydro-1H-imidazole hydroiodide

HRID 588957ノート

反応式

HRID 588957 の反応式
[CH3:1][N:2]1[CH2:6][CH2:5][NH:4][C:3]1=[S:7].[CH3:8][I:9]>CC(C)=O>[IH:9].[CH3:1][N:2]1[CH2:6][CH2:5][N:4]=[C:3]1[S:7][CH3:8]

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 2733224Methylethylenethiourea

生成物 1

HCID 122815051-methyl-2-(methylsulfanyl)-4,5-dihydro-1H-imidazole hydroiodide収率 77%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a suspension of 1-methylimidazolidine-2-thione (5.17 g, 44.5 mmol) in acetone (50 mL) was added MeI (2.9 mL, 46.6 mmol). The solution was allowed to stir at room temperature for 4 h and the resulting solid was quickly filtered and then dried in vacuo to give 1-methyl-2-(methylthio)-4,5-dihydro-1H-imidazole hydroiodide (8.79 g, 77%) as beige solid.

後処理

  1. filtrationthe resulting solid was quickly filtered
  2. customdried in vacuo

出典と根拠

ORDレコード
ord-7f9207390227430fa1f29728097c2db3
出典データセット
uspto-grants-2016_01
特許番号
US09227961B2

反応ノート

読み込み中…