Bromine → HCID 86732529、化合物

HRID 589026

反応式

HRID 589026 の反応式
[Br:1]Br.[O:3]=[C:4]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)[CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7]>C(Cl)(Cl)Cl>[BrH:1].[Br:1][CH:5]([C:4](=[O:3])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7]

参加物

4

反応物 2

HCID 24408BromineHCID 2736461Ethyl 3-oxo-3-(pyridin-2-yl)propanoate

生成物 1

HCID 86732529HCID 86732529、化合物収率 196.1%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

Bromine (0.83 g, 5.2 mmol) in chloroform (2 mL) was added slowly to a solution of ethyl 3-oxo-3-pyridin-2-ylpropanoate (1.0 g, 5.2 mmol) and chloroform (25.0 mL) at room temperature. The reaction mixture was stirred for 1 h and was concentrated under reduced pressure to give 1 ethyl 2-bromo-3-oxo-3-pyridin-2-ylpropanoate hydrobromide salt as an amber oil (1.8 g, 100%). LCMS calc. for C10H11BrNO3 (M+H)+: m/z=272.0, 274.0. found: 272.0, 274.0.

後処理

  1. concentrationwas concentrated under reduced pressure

出典と根拠

ORDレコード
ord-0329859aee474515871bea3be49a8efd
出典データセット
uspto-grants-2016_01
特許番号
US09227985B2

関連ノート

読み込み中…