1-(5-Bromopyrimidin-2-yl)ethan-1-one → 2-(5-Bromopyrimidin-2-yl)propan-2-ol

HRID 589170ノート

反応式

HRID 589170 の反応式
[Br:1][C:2]1[CH:3]=[N:4][C:5]([C:8](=[O:10])[CH3:9])=[N:6][CH:7]=1.[CH3:11][Mg]Br>C1COCC1>[Br:1][C:2]1[CH:3]=[N:4][C:5]([C:8]([OH:10])([CH3:11])[CH3:9])=[N:6][CH:7]=1

参加物

4

反応物 2

HCID 534880641-(5-Bromopyrimidin-2-yl)ethan-1-oneHCID 178418573HCID 178418573、化合物

生成物 1

HCID 584852862-(5-Bromopyrimidin-2-yl)propan-2-ol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirred solution of 1-(5-bromopyrimidin-2-yl)ethanone (100 mg, 0.5 mmol) in THF (10 mL) at −78° C. was added methylmagnesium bromide (1.4M solution, 3.6 mL, 5 mmol). The reaction mixture was stirred for an additional 20 minutes until LC/MS analysis indicated that the reaction was complete. Quenching with saturated NH4Cl, extraction with EtOAc and drying over MgSO4, afforded the crude residue which was taken forward as is in the next step.

後処理

  1. customQuenching with saturated NH4Cl, extraction with EtOAc
  2. dry with materialdrying over MgSO4

出典と根拠

ORDレコード
ord-ef0297078d904383861d5ebed6d1655c
出典データセット
uspto-grants-2016_01
特許番号
US09227971B2

反応ノート

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