1-Methanesulfonyl-piperidine-4-carboxylic acid benzyl ester → 1-Methanesulfonylpiperidine-4-carboxylic acid
反応式
C([O:8][C:9]([CH:11]1[CH2:16][CH2:15][N:14]([S:17]([CH3:20])(=[O:19])=[O:18])[CH2:13][CH2:12]1)=[O:10])C1C=CC=CC=1>C(OCC)(=O)C.CO.[Pd]>[CH3:20][S:17]([N:14]1[CH2:15][CH2:16][CH:11]([C:9]([OH:10])=[O:8])[CH2:12][CH2:13]1)(=[O:19])=[O:18]参加物
5
実験手順
1-Methanesulfonyl-piperidine-4-carboxylic acid benzyl ester (0.8 g, 26.7 mmol) from step 4, was dissolved in ethyl acetate (100 ml) and methanol (10 ml), Pd/C 10% (80 mg) was added and the resulting mixture was hydrogenated at 1 bar. The catalyst was filtered over celite, the solvent was removed under reduced pressure to give a white solid. Yield 73%, 0.4 g
後処理
- filtrationThe catalyst was filtered over celite
- customthe solvent was removed under reduced pressure
- customto give a white solid
出典と根拠
- ORDレコード
- ord-225dcdbf5dfe458cac1b8eed46071949
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09233115B2
反応ノート
読み込み中…