ethyl 2-[2-methyl-3-(4-nitrobenzyl)-1H-indol-1-yl]acetate → HCID 89590249、化合物

HRID 589338ノート

反応式

HRID 589338 の反応式
[CH3:1][C:2]1[N:3]([CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])[C:4]2[C:9]([C:10]=1[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][CH:13]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2>CO.[Pd]>[NH2:18][C:15]1[CH:14]=[CH:13][C:12]([CH2:11][C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]([CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])[C:2]=2[CH3:1])=[CH:17][CH:16]=1

参加物

4

反応物 1

HCID 89590291ethyl 2-[2-methyl-3-(4-nitrobenzyl)-1H-indol-1-yl]acetate

生成物 1

HCID 89590249HCID 89590249、化合物収率 92.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Into a dry reaction vessel, ethyl 2-[2-methyl-3-(4-nitrobenzyl)-1H-indol-1-yl]acetate (2.7 g, 7.66 mmol) was added, and dissolved in 30 mL methanol. 10% Pd/C 300 mg was added, purged with hydrogen, and reacted overnight. After completion of the reaction, it was filtered, and the filter cake was washed with methanol. The filtrate was rotate evaporated to dryness to obtain a white solid 2.28 g, at a yield of 92.3%.

後処理

  1. additionwas added
  2. custompurged with hydrogen
  3. customreacted overnight
  4. customAfter completion of the reaction, it
  5. filtrationwas filtered
  6. washthe filter cake was washed with methanol
  7. customThe filtrate was rotate evaporated to dryness

出典と根拠

ORDレコード
ord-d107c81be49a4042b277ff6bf056454e
出典データセット
uspto-grants-2016_01
特許番号
US09233098B2

反応ノート

読み込み中…