Ethyl bromoacetate → ethyl 2-[3-(4-nitrobenzyl)-1H-indazol-1-yl]acetate

HRID 589347ノート

反応式

HRID 589347 の反応式
[N+:1]([C:4]1[CH:19]=[CH:18][C:7]([CH2:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][N:10]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].Br[CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23].C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])[N:10]=2)=[CH:18][CH:19]=1)([O-:3])=[O:2]

参加物

5

反応物 3

HCID 7748Ethyl bromoacetateHCID 10796Cesium carbonateHCID 178526610HCID 178526610、化合物

生成物 1

HCID 89590255ethyl 2-[3-(4-nitrobenzyl)-1H-indazol-1-yl]acetate収率 48.6%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Into a dry reaction vessel, 2.15 g (8.49 mmol) 3-(4-nitrobenzyl)-1H-indazole, 10 mL DMF, 1.70 g (10.2 mmol) ethyl bromoacetate, 5.54 g (17.0 mmol) cesium carbonate were respectively added, and reacted at room temperature overnight. It was chromatographed on a column to obtain 1.4 g red solid, at a yield of 48.5%.

後処理

  1. additionwere respectively added
  2. customreacted at room temperature overnight
  3. customIt was chromatographed on a column

出典と根拠

ORDレコード
ord-9520289e1d3d438b8be038dc166cd41b
出典データセット
uspto-grants-2016_01
特許番号
US09233098B2

反応ノート

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