ethyl 2-[3-(4-nitrobenzyl)-1H-indazol-1-yl]acetate → ethyl 2-[3-(4-aminobenzyl)-1H-indazol-1-yl]acetate

HRID 589348ノート

反応式

HRID 589348 の反応式
[N+:1]([C:4]1[CH:25]=[CH:24][C:7]([CH2:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:10]=2)=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:10]=2)=[CH:24][CH:25]=1

参加物

4

反応物 1

HCID 89590255ethyl 2-[3-(4-nitrobenzyl)-1H-indazol-1-yl]acetate

生成物 1

HCID 89590284ethyl 2-[3-(4-aminobenzyl)-1H-indazol-1-yl]acetate収率 53.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

1.3 g (3.83 mmol) ethyl 2-[3-(4-nitrobenzyl)-1H-indazol-1-yl]acetate was dissolved in 40 mL methanol. 200 mg palladium on carbon was added, and reacted under an atmosphere of H2 at room temperature overnight. It was filtered to remove solid, rotate evaporated to dryness to remove the solvent, and separated by a preparative chromatography to obtain a white solid 630 mg, at a yield of 53.3%.

後処理

  1. customreacted under an atmosphere of H2 at room temperature overnight
  2. filtrationIt was filtered
  3. customto remove solid
  4. customrotate evaporated to dryness
  5. customto remove the solvent
  6. customseparated by a preparative chromatography

出典と根拠

ORDレコード
ord-3980d90367aa4ddeb7b4f496eaec4e9a
出典データセット
uspto-grants-2016_01
特許番号
US09233098B2

反応ノート

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