Ethyl bromoacetate → ethyl 2-[2-ethyl-3-(4-nitrobenzyl)-1H-indol-1-yl]acetate

反応式

[CH2:1]([C:3]1[NH:4][C:5]2[C:10]([C:11]=1[CH2:12][C:13]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][CH:14]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH3:2].C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH2:29][C:30]([O:32][CH2:33][CH3:34])=[O:31]>CN(C=O)C>[CH2:1]([C:3]1[N:4]([CH2:29][C:30]([O:32][CH2:33][CH3:34])=[O:31])[C:5]2[C:10]([C:11]=1[CH2:12][C:13]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][CH:14]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH3:2]

参加物

実験手順

2-Ethyl-3-(4-nitrobenzyl)-1H-indole (3.0 g, 10.7 mmol) was weighed, and dissolved in 30 mL DMF. Cesium carbonate (6.98 g, 21.4 mmol) was added, and stirred at room temperature for 15 min. Ethyl bromoacetate (1.97 g, 11.8 mmol) was added, reacted at room temperature for 10 h, and filtered. The filtrate was added into water, and extracted with ethyl acetate. The extract was washed with water and a saturated solution of sodium chloride, rotate evaporated to dryness, purified by preparative liquid phase to obtain a yellow solid 350 mg, at a yield of 8.97%.