Hydrochloric Acid → 2-[1-[4-(2-naphthamido)benzyl]-1H-indazol-3-yl]acetic acid

HRID 589367ノート

反応式

HRID 589367 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]([NH:13][C:14]1[CH:35]=[CH:34][C:17]([CH2:18][N:19]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[C:21]([CH2:28][C:29]([O:31]CC)=[O:30])=[N:20]2)=[CH:16][CH:15]=1)=[O:12].O.[OH-].[Li+].O.Cl>O1CCCC1>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]([NH:13][C:14]1[CH:15]=[CH:16][C:17]([CH2:18][N:19]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[C:21]([CH2:28][C:29]([OH:31])=[O:30])=[N:20]2)=[CH:34][CH:35]=1)=[O:12]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 90449170ethyl 2-[1-[4-(2-naphthamido)benzyl]-1H-indazol-3-yl]acetate

生成物 1

HCID 715568942-[1-[4-(2-naphthamido)benzyl]-1H-indazol-3-yl]acetic acid収率 58%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Ethyl 2-[1-[4-(2-naphthamido)benzyl]-1H-indazol-3-yl]acetate (226 mg, 0.488 mmol) was dissolved in tetrahydrofuran (10 mL), and in an ice bath 10 mL aqueous solution of lithium hydroxide monohydrate (62 mg, 1.48 mmol) was added. It was reacted at room temperature for 3 h, and the reaction was monitored to be complete by TLC. Water was added into the system, and adjusted to pH≈3-4 with diluted hydrochloric acid. A solid precipitated. It was filtered, and dried to obtain a white solid 123 mg, at a yield of 58%.

後処理

  1. customIt was reacted at room temperature for 3 h
  2. customA solid precipitated
  3. filtrationIt was filtered
  4. customdried

出典と根拠

ORDレコード
ord-d18a1ceefe2849e8b030f2d3b8184a59
出典データセット
uspto-grants-2016_01
特許番号
US09233098B2

反応ノート

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