Ethyl Acetate → ethyl 2-[1-(4-aminobenzyl)-1H-indazol-3-yl]acetate

HRID 589384ノート

反応式

HRID 589384 の反応式
[N+:1]([C:4]1[CH:25]=[CH:24][C:7]([CH2:8][N:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[N:10]2)=[CH:6][CH:5]=1)([O-])=O.C(OCC)(=O)C>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][N:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[N:10]2)=[CH:24][CH:25]=1

参加物

5

反応物 2

HCID 8857Ethyl AcetateHCID 89590252ethyl 2-[1-(4-nitrobenzyl)-1H-indazol-3-yl]acetate

生成物 1

HCID 89590263ethyl 2-[1-(4-aminobenzyl)-1H-indazol-3-yl]acetate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Ethyl 2-[1-(4-nitrobenzyl)-1H-indazol-3-yl]acetate (340 mg, 1.0 mmol) was dissolved in methanol (20 mL). 10% Pd/C(20 mg) was added, and reacted under hydrogen atmosphere for half an hour. TLC (petroleum ether:ethyl acetate=2:1) indicated that starting material disappeared. It was filtered to remove solid, rotate evaporated to dryness to remove the solvent, and the resulting solid was used for the next step directly.

後処理

  1. customreacted under hydrogen atmosphere for half an hour
  2. filtrationIt was filtered
  3. customto remove solid
  4. customrotate evaporated to dryness
  5. customto remove the solvent

出典と根拠

ORDレコード
ord-5c52bbc6a9eb4cffb75ed22df009f2e4
出典データセット
uspto-grants-2016_01
特許番号
US09233098B2

反応ノート

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