Oxalyl chloride → 6-Fluoro-2-naphthoyl chloride

HRID 589385

反応式

HRID 589385 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([OH:14])=O)[CH:6]=[CH:5]2.C(Cl)(=O)C([Cl:18])=O>ClCCl.CN(C)C=O>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([Cl:18])=[O:14])[CH:6]=[CH:5]2

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 27827886-Fluoro-2-naphthoic acid

生成物 1

HCID 866748346-Fluoro-2-naphthoyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 6344Dichloromethane溶媒

実験手順

6-Fluoro-2-naphthoic acid (228 mg, 1.2 mmol) was dissolved in dichloromethane (15 mL) and N,N-dimethylformamide (0.1 mL), and in an ice bath oxalic chloride (228 mg, 1.8 mmol) was added dropwise slowly. Upon completion of the dropwise addition, it was moved to react at room temperature for 3 hours, and concentrated under reduce pressure to obtain a white solid, i.e. 6-fluoro-2-naphthoyl chloride.

後処理

  1. additionUpon completion of the dropwise addition, it
  2. customto react at room temperature for 3 hours
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-a0b272b1e5734728a4e677fa84822678
出典データセット
uspto-grants-2016_01
特許番号
US09233098B2

関連ノート

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