Oxalyl chloride → 6-Methylnicotinoyl chloride
反応式
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][N:3]=1.C(Cl)(=O)C([Cl:14])=O>ClCCl.CN(C)C=O>[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:14])=[O:7])=[CH:4][N:3]=1参加物
5
実験手順
6-Methyl nicotinic acid (138 mg, 1.00 mmol) was dissolved in dichloromethane (15 mL) and N,N-dimethylformamide (0.10 mL), and in an ice bath oxalic chloride (192 mg, 1.51 mmol) was added dropwise slowly. Upon completion of the dropwise addition, it was moved to react at room temperature for 3 hours, and concentrated under reduce pressure to obtain 6-methyl nicotinoyl chloride as a white solid.
後処理
- additionUpon completion of the dropwise addition, it
- customto react at room temperature for 3 hours
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-9a433cafe5f24ab28e3d3a27ecdb497b
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09233098B2
反応ノート
読み込み中…