Sodium Hydroxide → 2-Nitro-6-(pyridin-2-yl)aniline

HRID 589471ノート

反応式

HRID 589471 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)[C:5]=1[NH:16]C(=O)C)([O-:3])=[O:2].[OH-].[Na+]>CO>[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)[C:5]=1[NH2:16])([O-:3])=[O:2]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 86701070N-(2-nitro-6-(pyridin-2-yl)phenyl)acetamide

生成物 1

HCID 130010352-Nitro-6-(pyridin-2-yl)aniline収率 65.9%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of N-(2-nitro-6-(pyridin-2-yl)phenyl)acetamide (XCVIII) (4.41 g, 17 mmol, 1 eq) in MeOH (20 mL) was added 2N NaOH aqueous (50 mL) and the mixture was refluxed until the stirring material was consumed completely. The mixture was concentrated in vacuo to remove the MeOH and the precipitate was collected by filtration to afford 2-nitro-6-(pyridin-2-yl)aniline (XCIX) (2.4 g, 11.2 mmol, 65% yield) as a yellow solid. ESIMS found for C11H9N3O2 m/z 216 (M+H).

後処理

  1. temperaturethe mixture was refluxed until the stirring material
  2. customwas consumed completely
  3. concentrationThe mixture was concentrated in vacuo
  4. customto remove the MeOH
  5. filtrationthe precipitate was collected by filtration

出典と根拠

ORDレコード
ord-4ff0d2a906de46709e5ea4b26106f7f3
出典データセット
uspto-grants-2016_01
特許番号
US09233104B2

反応ノート

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