Water → 3-(3-Pyridinyl)-5-isoxazolecarboxylic acid

HRID 589622ノート

反応式

HRID 589622 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:11]=[C:10]([C:12]([O:14]CC)=[O:13])[O:9][N:8]=2)[CH:2]=1.O.[OH-].[Na+]>O1CCOCC1>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:11]=[C:10]([C:12]([OH:14])=[O:13])[O:9][N:8]=2)[CH:2]=1

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 776521HCID 776521、化合物

生成物 1

HCID 290785823-(3-Pyridinyl)-5-isoxazolecarboxylic acid

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

300 mg (1.38 mmol) of ethyl 3-(pyridin-3-yl)-1,2-oxazole-5-carboxylate (for preparation see Chem. Heterocyclic Comp. 2000, 36, 1226-1231) were dissolved in 20 ml of dioxane. While cooling with ice, 7 ml of water and 0.35 ml of 45% aqueous sodium hydroxide solution were added to the solution. The mixture was stirred at room temperature for two hours, then the dioxane was removed on a rotary evaporator under reduced pressure. Ice-water was added to the residue, and it was acidified with concentrated hydrochloric acid. The solution was stirred at room temperature overnight, and the precipitated solid was filtered off with suction and dried.

後処理

  1. additionwere added to the solution
  2. customthe dioxane was removed on a rotary evaporator under reduced pressure
  3. additionIce-water was added to the residue, and it
  4. stirringThe solution was stirred at room temperature overnight
  5. filtrationthe precipitated solid was filtered off with suction
  6. customdried

出典と根拠

ORDレコード
ord-f795165e54a5481097bbdd1e2d72c3c2
出典データセット
uspto-grants-2016_01
特許番号
US09233951B2

反応ノート

読み込み中…