Oxalyl chloride → HCID 82371400、化合物

HRID 589623ノート

反応式

HRID 589623 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:11]=[C:10]([C:12]([OH:14])=O)[O:9][N:8]=2)[CH:2]=1.C(Cl)(=O)C([Cl:18])=O>ClCCl.CN(C=O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:11]=[C:10]([C:12]([Cl:18])=[O:14])[O:9][N:8]=2)[CH:2]=1

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 290785823-(3-Pyridinyl)-5-isoxazolecarboxylic acid

生成物 1

HCID 82371400HCID 82371400、化合物

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

600 mg (3.16 mmol) of 3-(pyridin-3-yl)-1,2-oxazole-5-carboxylic acid were initially charged in dichloromethane, and three drops of DMF were added. 1.16 g (9.15 mmol) of oxalyl chloride were added dropwise under argon (vigorous evolution of gas). The reaction solution was stirred at room temperature and then the solvent was removed on a rotary evaporator. 30 ml of toluene were added to the residue. After the toluene had been removed on a rotary evaporator, the residue was converted further directly.

後処理

  1. customthe solvent was removed on a rotary evaporator
  2. addition30 ml of toluene were added to the residue
  3. customAfter the toluene had been removed on a rotary evaporator

出典と根拠

ORDレコード
ord-1b8b0257fd81439c80551f19f08bec0a
出典データセット
uspto-grants-2016_01
特許番号
US09233951B2

反応ノート

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