Pyridine → 3-{[(5-Methyl-1-benzothiophen-2-yl)sulfonyl]amino}benzoic acid

HRID 589758ノート

反応式

HRID 589758 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10](Cl)(=[O:12])=[O:11])=[CH:7][C:6]=2[CH:14]=1.N1C=CC=CC=1.[NH2:21][C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=1)[C:25]([OH:27])=[O:26]>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10]([NH:21][C:22]3[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=3)[C:25]([OH:27])=[O:26])(=[O:12])=[O:11])=[CH:7][C:6]=2[CH:14]=1

参加物

4

反応物 3

HCID 1049PyridineHCID 74193-Aminobenzoic AcidHCID 27947715-Methyl-1-benzothiophene-2-sulfonyl chloride

生成物 1

HCID 569421703-{[(5-Methyl-1-benzothiophen-2-yl)sulfonyl]amino}benzoic acid収率 66%

実験手順

The product was prepared according to General Procedure 6, described in Example 65, with 5-methylbenzothiophene-2-sulfonyl chloride (30.0 mg, 0.12 mmol), pyridine (49 μL, 0.61 mmol) and 3-aminobenzoic acid (16.7 mg, 0.10 mmol). The title compound was obtained in 66% yield (23 mg). MS (ESI+) calcd mass for C16H13NO4S2 347.028599, found 347.029559.

後処理

  1. customThe product was prepared

出典と根拠

ORDレコード
ord-43f0009af29b4f1eb3930f4bc13f82ac
出典データセット
uspto-grants-2016_01
特許番号
US09233946B2

反応ノート

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