Sodium Carbonate → Ticagrelor

HRID 589829ノート

反応式

HRID 589829 の反応式
[CH3:1][CH2:2][CH2:3][S:4][C:5]1[N:6]=[C:7]([NH:25][C@H:26]2[C@H:28]([C:29]3[CH:30]=[CH:31][C:32]([F:36])=[C:33]([F:35])[CH:34]=3)[CH2:27]2)[C:8]2[N:13]=[N:12][N:11]([C@H:14]3[C@H:18]([OH:19])[C@H:17]([OH:20])[C@@H:16]([O:21][CH2:22][CH2:23][OH:24])[CH2:15]3)[C:9]=2[N:10]=1.C([O-])(=O)CC([O-])=O.C(=O)([O-])[O-].[Na+].[Na+]>C(OCC)(=O)C>[CH3:1][CH2:2][CH2:3][S:4][C:5]1[N:6]=[C:7]([NH:25][C@H:26]2[C@H:28]([C:29]3[CH:30]=[CH:31][C:32]([F:36])=[C:33]([F:35])[CH:34]=3)[CH2:27]2)[C:8]2[N:13]=[N:12][N:11]([C@H:14]3[C@H:18]([OH:19])[C@H:17]([OH:20])[C@@H:16]([O:21][CH2:22][CH2:23][OH:24])[CH2:15]3)[C:9]=2[N:10]=1

参加物

4

反応物 2

HCID 10340Sodium CarbonateHCID 131734470Ticagrelor malonate

生成物 1

HCID 9871419Ticagrelor

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Ticagrelor malonate (0.5 g) and ethyl acetate (10 mL) were charged into round bottom flask. To the mixture 10% aqueous sodium carbonate solution (50 mL) was added and mixture was stirred for 15 minutes. The layers were separated and organic layer was subjected to distillation under vacuum to afford the title compound.

後処理

  1. customThe layers were separated
  2. distillationorganic layer was subjected to distillation under vacuum

出典と根拠

ORDレコード
ord-31246c698edb43a1919f28f4968f9693
出典データセット
uspto-grants-2016_01
特許番号
US09233966B2

反応ノート

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