Sulfuryl chloride → N-cyclobutylsulfamoyl chloride

HRID 589953ノート

反応式

HRID 589953 の反応式
[S:1]([Cl:5])(Cl)(=[O:3])=[O:2].Cl.[CH:7]1([NH2:11])[CH2:10][CH2:9][CH2:8]1>CC#N>[CH:7]1([NH:11][S:1]([Cl:5])(=[O:3])=[O:2])[CH2:10][CH2:9][CH2:8]1

参加物

4

反応物 2

HCID 24648Sulfuryl chlorideHCID 12618374Cyclobutanamine, hydrochloride (1:1)

生成物 1

HCID 22326606N-cyclobutylsulfamoyl chloride

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Sulfuryl chloride (104 mmol) was dissolved in dry CH3CN (25 mL), added cyclobutylamine hydrochloride (31 mmol) and stirred at reflux for 16 h. The obtained reaction mixture was cooled to rt and concentrated in vacuo. The obtained residue was trituated with Et2O (2×25 mL). The combined Et2O-phases were concentrated in vacuo affording the title compound as oil.

後処理

  1. temperatureat reflux for 16 h
  2. customThe obtained reaction mixture
  3. concentrationconcentrated in vacuo
  4. concentrationThe combined Et2O-phases were concentrated in vacuo

出典と根拠

ORDレコード
ord-62c3fc2be6e84f288f350fcd29fe402c
出典データセット
uspto-grants-2016_01
特許番号
US09233964B2

反応ノート

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