Sodium borohydride → N-[(4-methoxyphenyl)methyl]-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6](/[CH:9]=[N:10]\[S:11]([N:14]2[C:19]3([CH2:21][CH2:20]3)[CH2:18][N:17]([C:22]3[C:23]4[CH:30]=[CH:29][NH:28][C:24]=4[N:25]=[CH:26][N:27]=3)[CH2:16][CH2:15]2)(=[O:13])=[O:12])=[CH:5][CH:4]=1.[BH4-].[Na+]>CO>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][NH:10][S:11]([N:14]2[C:19]3([CH2:20][CH2:21]3)[CH2:18][N:17]([C:22]3[C:23]4[CH:30]=[CH:29][NH:28][C:24]=4[N:25]=[CH:26][N:27]=3)[CH2:16][CH2:15]2)(=[O:13])=[O:12])=[CH:5][CH:4]=1参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
(NZ)—N-[(4-methoxyphenyl)methylene]-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide (intermediate 49) was dissolved in MeOH, added NaBH4 (1 eq) and stirred at rt for 2 h. The pure compound was obtained by standard preparative HPLC purification of the reaction mixture.