HCID 118271795、化合物 → (αS)-α-(1-Methoxy-1-methylethyl)benzenemethanamine

HRID 590792ノート

反応式

HRID 590792 の反応式
[CH3:1][O:2][C:3]([CH3:31])([CH3:30])[C@H:4]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[N:5](CC1C=CC(OC)=CC=1)CC1C=CC(OC)=CC=1>CO.[Pd]>[CH3:1][O:2][C:3]([CH3:31])([CH3:30])[C@H:4]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[NH2:5]

参加物

4

反応物 1

HCID 118271795HCID 118271795、化合物

生成物 1

HCID 57791001(αS)-α-(1-Methoxy-1-methylethyl)benzenemethanamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of (S)-2-methoxy-N,N-bis(4-methoxybenzyl)-2-methyl-1-phenylpropan-1-amine (0.7 g, 1.67 mmol) in anhydrous MeOH was added Pd on C (0.1 g) and the contents were stirred at ambient temperature in H2 atmosphere. After 14 h, the reaction mixture was filtered through a pad of celite and the volatiles were removed under reduced pressure. The residue thus obtained was further purified by preparative HPLC to afford the title compound. H1NMR (ppm, 400 MHz, CDCl3) δ 7.45-7.44 (m, 2H), 7.35-7.33 (m, 3H), 4.1 (s, 1H), 3.32 (s, 3H), 1.2 (s, 3H), 1.12 (s, 3H).

後処理

  1. filtrationthe reaction mixture was filtered through a pad of celite
  2. customthe volatiles were removed under reduced pressure
  3. customThe residue thus obtained
  4. customwas further purified by preparative HPLC

出典と根拠

ORDレコード
ord-010482e02de149218431703cedb3e785
出典データセット
uspto-grants-2016_01
特許番号
US09233979B2

反応ノート

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