N-bromobutanimide → methyl 2-(2-bromo-1-methyl-1H-indol-3-yl)pentanoate

HRID 590999ノート

反応式

HRID 590999 の反応式
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]([CH2:16][CH2:17][CH3:18])[C:12]([O:14][CH3:15])=[O:13])=[CH:3]1.[Br:19]N1C(=O)CCC1=O>ClC(Cl)(Cl)Cl>[Br:19][C:3]1[N:2]([CH3:1])[C:10]2[C:5]([C:4]=1[CH:11]([CH2:16][CH2:17][CH3:18])[C:12]([O:14][CH3:15])=[O:13])=[CH:6][CH:7]=[CH:8][CH:9]=2

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 70817995methyl 2-(1-methyl-1H-indol-3-yl)pentanoate

生成物 1

HCID 70819053methyl 2-(2-bromo-1-methyl-1H-indol-3-yl)pentanoate

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

A solution of methyl 2-(1-methyl-1H-indol-3-yl)pentanoate (12b) (860 mg, 3.44 mmol) and N-bromosuccinimide (623 mg, 3.5 mmol) in tetrachloromethane (20 mL) was stirred at room temperature for 5 hours. The mixture was then filtered and the filtrate was washed with water (10 mL), brine (10 mL), dried over sodium sulfate, filtered and evaporated under reduced pressure to afford the desired product (12c) as a brown oil without further purification (1.13 g, 3.44 mmol, 100%).

後処理

  1. filtrationThe mixture was then filtered
  2. washthe filtrate was washed with water (10 mL), brine (10 mL)
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-b1dfad4959c743908bde6e7ed3469dce
出典データセット
uspto-grants-2016_01
特許番号
US09238026B2

反応ノート

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