関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-Fluoro-2-methoxy-4-nitrobenzene | HCID 14451968 | — |
| 反応物 | HCID 178493803 | HCID 178493803 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | HCID 117824150 | HCID 117824150 | 54.2% |
反応手順
1-Fluoro-2-methoxy-4-nitrobenzene (0.785 g, 4.59 mmol), 4-methoxy-1H-imidazole (0.45 g, 4.59 mmol) and potassium carbonate (0.697 g, 5.05 mmol) were mixed in dry acetonitrile (10 mL) and heated at 90° C. for 4 days. DCM was added and the mixture was filtrated through a pad of silica eluting with 5% MeOH in DCM. The solvents were evaporated and mixture was purified by column chromatography in silica eluting with a gradient of MeOH and DCM to give the title compound as a gum 0.62 g (54%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09439904B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-fdfba193e4ce4de8bd37a02c85fe590f |
|---|
| 出典メモ | uspto-grants-2016_09 |
|---|
