反应详情

温度

90 °C

1-Fluoro-2-methoxy-4-nitrobenzene (0.785 g, 4.59 mmol), 4-methoxy-1H-imidazole (0.45 g, 4.59 mmol) and potassium carbonate (0.697 g, 5.05 mmol) were mixed in dry acetonitrile (10 mL) and heated at 90° C. for 4 days. DCM was added and the mixture was filtrated through a pad of silica eluting with 5% MeOH in DCM. The solvents were evaporated and mixture was purified by column chromatography in silica eluting with a gradient of MeOH and DCM to give the title compound as a gum 0.62 g (54%).

1. filtrationthe mixture was filtrated through a pad of silica eluting with 5% MeOH in DCM
2. customThe solvents were evaporated
3. custommixture was purified by column chromatography in silica eluting with a gradient of MeOH and DCM