Triethylamine → 1-(2-Chloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-4-ylamino)-2-methylpropan-2-ol

1-Amino-2-methylpropan-2-ol hydrochloride (221 mg, 1.76 mmol) was suspended in MeOH (2 mL). Triethylamine (0.147 mL, 1.06 mmol) was added and the suspension was filtered. The filtrate was added to an ice-cold solution of 2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)-pyrimidine (92 mg, 0.35 mmol) in acetonitrile (2 mL). The mixture was stirred for 1 h at rt. The mixture was purified by preparative HPLC to give the title compound (35 mg, 32%).

1. filtrationthe suspension was filtered
2. customThe mixture was purified by preparative HPLC

ORDレコード

ord-bf500ce66b424f97b4f9bdfd3fce0bff

出典データセット

uspto-grants-2016_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09439904B2