Sodium Chloride → 3-Amino-2-imino-6-methyl-2,3-dihydropyrimidin-4(1H)-one
反応式
CC[O-].[Na+].[Na].[C:6]([NH:9][NH2:10])([NH2:8])=[NH:7].Cl.[Na+].[Cl-].O=[C:15]([CH3:22])[CH2:16][C:17](OCC)=[O:18]>C(O)C>[NH2:7][C:6]1[N:9]([NH2:10])[C:17](=[O:18])[CH:16]=[C:15]([CH3:22])[N:8]=1参加物
7
反応条件
- 温度
- 50 °C
実験手順
To a stirring solution of NaOEt prepared from sodium (FLUKA, 9.19 g, 400 mmol) and ethanol (350 mL) was added aminoguanidine hydrochloride (ALDRICH, 44.2 g, 400 mmol). The reaction mixture was heated at 50° C. for 30 min. Then, the mixture was filtered to remove NaCl, and ethyl 3-oxobutanoate (ALDRICH, 25.3 mL, 200 mmol) was added to the filtrate. The reaction mixture was heated under reflux for 5 h and, then, stirred at room temperature overnight. The precipitate obtained was filtered and dried under vacuum to afford Intermediate 1 as a pale pink solid.
後処理
- filtrationThen, the mixture was filtered
- additionwas added to the filtrate
- temperatureThe reaction mixture was heated
- temperatureunder reflux for 5 h
- customThe precipitate obtained
- filtrationwas filtered
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-14cd1255a38d4f75999a61648930ba35
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09238653B2
反応ノート
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