HCID 117778092、化合物 → di-tert-butyl 4-(4-hydroxybenzyl)-L-glutamate
反応式
C([O:8][C:9]1[CH:52]=[CH:51][C:12]([CH2:13][CH:14]([C:44]([O:46][C:47]([CH3:50])([CH3:49])[CH3:48])=[O:45])[CH2:15][C@@H:16]([C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])[NH:17]C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:13][CH:14]([C:44]([O:46][C:47]([CH3:50])([CH3:49])[CH3:48])=[O:45])[CH2:15][C@@H:16]([C:37]([O:39][C:40]([CH3:41])([CH3:42])[CH3:43])=[O:38])[NH2:17])=[CH:51][CH:52]=1参加物
4
実験手順
Di-tert-butyl 4-[4-(benzyloxy)benzyl]-N-trityl-L-glutamate (499 mg, 0.72 mmol) were dissolved in methanol (20 ml). Palladium (10% on charcoal) (228 mg; 214 μmol) was added and the suspension was shaken under a hydrogen atmosphere for 12 h. The reaction mixture was filtered through a pad of celite, concentrated under reduced pressure and the residue was purified by silica gel column chromatography to yield 75 mg (28.7%) of the product.