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Hydrochloric Acid → (6-((1,3-Dimethyl-1H-pyrazol-5-yl)methoxy)-4-methyl-1-benzothiophen-3-yl)acetic acid

HRID 591397
ノート
印刷プレビュー

反応式

HRID 591397 の反応式
C[O:2][C:3](=[O:24])[CH2:4][C:5]1[C:9]2[C:10]([CH3:23])=[CH:11][C:12]([O:14][CH2:15][C:16]3[N:20]([CH3:21])[N:19]=[C:18]([CH3:22])[CH:17]=3)=[CH:13][C:8]=2[S:7][CH:6]=1.[OH-].[Na+].Cl>CCO>[CH3:21][N:20]1[C:16]([CH2:15][O:14][C:12]2[CH:11]=[C:10]([CH3:23])[C:9]3[C:5]([CH2:4][C:3]([OH:24])=[O:2])=[CH:6][S:7][C:8]=3[CH:13]=2)=[CH:17][C:18]([CH3:22])=[N:19]1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 118667002Methyl(6-((1,3-dimethyl-1H-pyrazol-5-yl)methoxy)-4-methyl-1-benzothiophen-3-yl)acetate

生成物 1

HCID 89768917(6-((1,3-Dimethyl-1H-pyrazol-5-yl)methoxy)-4-methyl-1-benzothiophen-3-yl)acetic acid収率 79.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a mixture of methyl(6-((1,3-dimethyl-1H-pyrazol-5-yl)methoxy)-4-methyl-1-benzothiophen-3-yl)acetate (143 mg) and EtOH (2 mL) was added 1N NaOH (0.42 mL) at room temperature, and the mixture was refluxed for 30 min. The mixture was neutralized with 1N HCl at room temperature and extracted with EtOAc. The organic layer was separated, washed with brine, dried over MgSO4 and concentrated in vacuo. The residual solid was crystallized from EtOAc-hexane to give the title compound (109 mg).

後処理

  1. temperaturethe mixture was refluxed for 30 min
  2. extractionextracted with EtOAc
  3. customThe organic layer was separated
  4. washwashed with brine
  5. dry with materialdried over MgSO4
  6. concentrationconcentrated in vacuo
  7. customThe residual solid was crystallized from EtOAc-hexane

出典と根拠

ORDレコード
ord-9344cfa701e44ca588adc7afe2c440fe
出典データセット
uspto-grants-2016_01
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09238639B2

反応ノート

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