Hydrochloric Acid → (4-Ethyl-2-methyl-1,3-thiazol-5-yl)methanol

HRID 591497ノート

反応式

HRID 591497 の反応式
[CH2:1]([C:3]1[N:4]=[C:5]([CH3:11])[S:6][C:7]=1[C:8](O)=[O:9])[CH3:2].Cl>C1COCC1>[CH2:1]([C:3]1[N:4]=[C:5]([CH3:11])[S:6][C:7]=1[CH2:8][OH:9])[CH3:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 146487654-Ethyl-2-methyl-1,3-thiazole-5-carboxylic acid

生成物 1

HCID 37134637(4-Ethyl-2-methyl-1,3-thiazol-5-yl)methanol収率 34%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a borane tetrahydrofuran complex solution (1.2 M in THF, 5 mL) was added 4-ethyl-2-methylthiazole-5-carboxylic acid (400 mg) at 0° C. The mixture was stirred at 0° C. to room temperature under argon atmosphere overnight. To the mixture was added 1N HCl at room temperature, and the mixture was extracted with EtOAc. The organic layer was separated, washed successively with brine and water, dried over Na2SO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/hexane) to give the title compound (125 mg).

後処理

  1. extractionthe mixture was extracted with EtOAc
  2. customThe organic layer was separated
  3. washwashed successively with brine and water
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated in vacuo
  6. customThe residue was purified by silica gel column chromatography (EtOAc/hexane)

出典と根拠

ORDレコード
ord-0c58eb5110d94b3c996c563aa287aedd
出典データセット
uspto-grants-2016_01
特許番号
US09238639B2

反応ノート

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