4-(Dimethylamino)-2-methoxybenzaldehyde → HCID 178493178、化合物

HRID 591929

反応式

HRID 591929 の反応式
FC(F)(F)C(O)=O.ClC1C(N[C@@H]2[C@@H]3C[C@@H](C=C3)[C@@H]2C(N)=O)=C2N=C(C3C=CC(CN4CCOCC4)=CC=3)NC2=NC=1.[NH2:42][C:43]1[C:48]([NH2:49])=[C:47]([NH:50][C@@H:51]2[C@@H:56]3[CH2:57][C@@H:53]([CH:54]=[CH:55]3)[C@@H:52]2[C:58]([NH2:60])=[O:59])[C:46]([Cl:61])=[CH:45][N:44]=1.[CH3:62][N:63]([CH3:74])[C:64]1[CH:71]=[CH:70][C:67]([CH:68]=O)=[C:66]([O:72][CH3:73])[CH:65]=1>>[Cl:61][C:46]1[C:47]([NH:50][C@@H:51]2[C@@H:56]3[CH2:57][C@@H:53]([CH:54]=[CH:55]3)[C@@H:52]2[C:58]([NH2:60])=[O:59])=[C:48]2[N:49]=[C:68]([C:67]3[CH:70]=[CH:71][C:64]([N:63]([CH3:74])[CH3:62])=[CH:65][C:66]=3[O:72][CH3:73])[NH:42][C:43]2=[N:44][CH:45]=1

参加物

4

反応物 3

HCID 2913504-(Dimethylamino)-2-methoxybenzaldehydeHCID 117701912(1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amideHCID 178513995HCID 178513995、化合物

生成物 1

HCID 178493178HCID 178493178、化合物収率 52%

実験手順

In the same fashion as for Compound III, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 4-Dimethylamino-2-methoxy-benzaldehyde were reacted to produce the title compound (52%). 1H NMR (d-chloroform): 13.60 (br s, 1H), 8.16 (d, J=9 Hz, 1H), 7.79 (s, 1H), 7.44 (br s, 1H), 6.35-6.50 (m, 3H), 6.24 (d, J=2 Hz, 1H), 5.94 (s, 1H), 5.43 (t, J=8 Hz, 1H), 5.31 (br s, 1H), 4.16 (s, 3H), 3.27 (s, 1H), 3.10 (s, 6H), 3.02 (s, 1H), 2.72 (d, J=8 Hz, 1H), 2.35 (d, J=9 Hz, 1H), 1.70 (d, J=10 Hz, 1H). MS: 454.07 (M+H). HPLC retention time: 2.61 minutes (G Method).

出典と根拠

ORDレコード
ord-d47ddb63e3644e90a2c59bc1cf8b1433
出典データセット
uspto-grants-2016_01
特許番号
US09238656B2

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