4-(Dimethylamino)-2-methoxybenzaldehyde → HCID 178493178、化合物

関与物質

反応手順

In the same fashion as for Compound III, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 4-Dimethylamino-2-methoxy-benzaldehyde were reacted to produce the title compound (52%). 1H NMR (d-chloroform): 13.60 (br s, 1H), 8.16 (d, J=9 Hz, 1H), 7.79 (s, 1H), 7.44 (br s, 1H), 6.35-6.50 (m, 3H), 6.24 (d, J=2 Hz, 1H), 5.94 (s, 1H), 5.43 (t, J=8 Hz, 1H), 5.31 (br s, 1H), 4.16 (s, 3H), 3.27 (s, 1H), 3.10 (s, 6H), 3.02 (s, 1H), 2.72 (d, J=8 Hz, 1H), 2.35 (d, J=9 Hz, 1H), 1.70 (d, J=10 Hz, 1H). MS: 454.07 (M+H). HPLC retention time: 2.61 minutes (G Method).

情報源と証拠