Hydrochloric Acid → 2-(3-Formylphenoxy)acetic acid
反応式
[CH:1]([C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][CH:15]=1)[O:6][CH2:7][C:8]([O:10]CC)=[O:9])=[O:2].[OH-].[Na+].Cl>CO>[CH:1]([C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][CH:15]=1)[O:6][CH2:7][C:8]([OH:10])=[O:9])=[O:2]参加物
5
実験手順
ethyl 2-(3-formylphenoxy)acetate (47)/(1 eq) was taken in MeOH and cooled to 0° C. when NaOH (2 eq) solution was added drop wise. After completion of addition the reaction mixture was stirred at rt for 30 min. The reaction mixture was cooled to rt and acidified with dil HCl to attain pH 3 when a precipitate appeared which was filtered and washed well with water and dried well to yield a white solid (49%). NMR: δ 4.754 (s, 1H), 7.23-7.27 (m, 1H), 7.349 (s, 1H), 7.449 (d, J=4.8 Hz, 2H), 9.938 (s, 1H), 13.07 (s, 1H).
後処理
- additionwas added drop wise
- additionAfter completion of addition the reaction mixture
- temperatureThe reaction mixture was cooled to rt
- filtrationwas filtered
- washwashed well with water
- customdried well
出典と根拠
- ORDレコード
- ord-b522a77d248e4268900a203f34313901
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09238656B2
反応ノート
読み込み中…