Trifluoroacetic acid → HCID 89726233、化合物

HRID 592088ノート

反応式

HRID 592088 の反応式
[CH:1]([C:3]1[CH:4]=[C:5]([CH:20]=[CH:21][CH:22]=1)[O:6][CH:7]1[CH2:12][CH2:11][N:10]([C:13](OC(C)(C)C)=[O:14])[CH2:9][CH2:8]1)=[O:2].C(O)([C:25]([F:28])([F:27])[F:26])=O>C(Cl)Cl>[F:26][C:25]([F:28])([F:27])[C:13]([N:10]1[CH2:11][CH2:12][CH:7]([O:6][C:5]2[CH:4]=[C:3]([CH:22]=[CH:21][CH:20]=2)[CH:1]=[O:2])[CH2:8][CH2:9]1)=[O:14]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 53439173tert-Butyl 4-(3-formylphenoxy)piperidine-1-carboxylate

生成物 1

HCID 89726233HCID 89726233、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

tert-butyl 4-(3-formylphenoxy)piperidine-1-carboxylate (61) (5.55 mmol) was taken in DCM and cooled to 0° C. when TFA (5 ml) was added drop wise and then stirred at rt for 16 h when TLC confirmed completion of reaction. The reaction mixture was concentrated and used directly for the next step. White solid.

後処理

  1. additionwas added drop wise
  2. customcompletion of reaction
  3. concentrationThe reaction mixture was concentrated

出典と根拠

ORDレコード
ord-3a4fccb6708048f1a3076f438139c3ae
出典データセット
uspto-grants-2016_01
特許番号
US09238656B2

反応ノート

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