4-(6-Nitropyridin-3-yl)piperazin-2-one → 4-(6-Aminopyridin-3-yl)piperazin-2-one

HRID 592175ノート

反応式

HRID 592175 の反応式
[N+:1]([C:4]1[N:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][NH:13][C:12](=[O:16])[CH2:11]2)=[CH:6][CH:5]=1)([O-])=O.[H][H]>[Pd].CO>[NH2:1][C:4]1[N:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][NH:13][C:12](=[O:16])[CH2:11]2)=[CH:6][CH:5]=1

参加物

5

反応物 2

HCID 584479234-(6-Nitropyridin-3-yl)piperazin-2-oneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 284115114-(6-Aminopyridin-3-yl)piperazin-2-one

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a round-bottom flask was added 4-(6-nitropyridin-3-yl)piperazin-2-one 141-3 (0.7 g, 3.1 mmol), Pd/C (0.2 g) and methanol (20 mL). The reaction was stirred for 4 hours under hydrogen atmosphere by attaching a hydrogen balloon. The reaction was flashed with nitrogen and the solid was removed by filtration. The solvent was removed by rotary evaporation to give 4-(6-aminopyridin-3-yl)piperazin-2-one 141-4 as purple solid. MS m/z 193.2 (M+1).

後処理

  1. customthe solid was removed by filtration
  2. customThe solvent was removed by rotary evaporation

出典と根拠

ORDレコード
ord-1a3a63fa56ed43e3944005f8dfbdf0a3
出典データセット
uspto-grants-2016_01
特許番号
US09238646B2

反応ノート

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