HCID 58447716、化合物 → 6-(3-Fluorophenyl)pyridin-3-amine

HRID 592250ノート

反応式

HRID 592250 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[H][H]>[Pd].CO>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[CH:10][C:11]([NH2:14])=[CH:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 58447716HCID 58447716、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 463118956-(3-Fluorophenyl)pyridin-3-amine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a round-bottom flask was added 2-(3-fluorophenyl)-5-nitropyridine (3.8 g, 17 mmol), Pd/C (0.5 g) and methanol (100 mL). The reaction was stirred for 4 hours under hydrogen atmosphere by attaching a hydrogen balloon. The reaction was flushed with nitrogen and the solid was removed by filtration. The solvent was removed by rotary evaporation to give 6-(3-fluorophenyl)pyridin-3-amine 219-1 as brown solid. MS m/z 189.1 (M+1).

後処理

  1. customThe reaction was flushed with nitrogen
  2. customthe solid was removed by filtration
  3. customThe solvent was removed by rotary evaporation

出典と根拠

ORDレコード
ord-d4a6464532694780ae8b79f19d2050bb
出典データセット
uspto-grants-2016_01
特許番号
US09238646B2

反応ノート

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