Hydrazine hydrate (1:1) → HCID 66690636、化合物

HRID 592293ノート

反応式

HRID 592293 の反応式
[Cl:1][C:2]1[C:3](Cl)=[N:4][CH:5]=[C:6]([CH:14]=1)[C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8].O.[NH2:17][NH2:18]>C(O)C>[Cl:1][C:2]1[C:3]([NH:17][NH2:18])=[N:4][CH:5]=[C:6]([CH:14]=1)[C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 10933837HCID 10933837、化合物

生成物 1

HCID 66690636HCID 66690636、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
75 °C

実験手順

To a solution of tert-butyl 5,6-dichloronicotinate (2.0 g, 8.1 mmol)) in ethanol (40.3 mL) was added hydrazine hydrate (1.18 mL, 24.2 mmol). The mixture was heated 75° C. After 18 h, the mixture was cooled to ambient temperature. The mixture was concentrated to dryness: LC-MS [M+1]=244.1.

後処理

  1. temperaturethe mixture was cooled to ambient temperature
  2. concentrationThe mixture was concentrated to dryness

出典と根拠

ORDレコード
ord-21237ceca1e849fc939313b08bfa33d0
出典データセット
uspto-grants-2016_01
特許番号
US09238647B2

反応ノート

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