Water → 1,2-Dimethyl-4-nitro-1H-imidazole

HRID 593183ノート

反応式

HRID 593183 の反応式
[CH3:1][C:2]1[NH:3][CH:4]=[C:5]([N+:7]([O-:9])=[O:8])[N:6]=1.[C:10]([O-])([O-])=O.[K+].[K+].CI.O>CN(C=O)C>[CH3:10][N:3]1[CH:4]=[C:5]([N+:7]([O-:9])=[O:8])[N:6]=[C:2]1[CH3:1]

参加物

6

反応物 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178433402HCID 178433402、化合物

生成物 1

HCID 257911,2-Dimethyl-4-nitro-1H-imidazole収率 45%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a mixture of 2-methyl-4-nitro-1H-imidazole (10.0 g, 78.7 mmol) and K2CO3 (21.7 g, 160 mmol) in DMF (80 mL) was added CH3I (13.4 g, 94 mmol) dropwise while stirring at room temperature. The mixture was stirred for 2 h. Water (200 mL) was then added to the mixture. The resulting suspension was filtered, washed with water, and dried in vacuo to afford 337a as a white solid (5.0 g, 45%). MS-ESI: [M+H]+ 142.1.

後処理

  1. stirringThe mixture was stirred for 2 h
  2. filtrationThe resulting suspension was filtered
  3. washwashed with water
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-cb96e0736dfa4b8d86d53d763c1f3edd
出典データセット
uspto-grants-2016_01
特許番号
US09238655B2

反応ノート

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