3-Bromopyridine-4-carboxaldehyde → (3-Bromopyridin-4-yl)methanol
反応式
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH:8]=[O:9].[BH4-].[Na+]>CO>[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH2:8][OH:9]参加物
4
実験手順
To a solution of 3-bromo-pyridine-4-carbaldehyde (0.500 g, 2.68 mmol) in MeOH (5 mL) at 0° C. is added sodium borohydride (0.122 g, 3.22 mmol). The mixture is stirred at room temperature for 1 h followed by removal of the solvent in vacuo. The residue is redissolved in DCM and washed with water twice. The organic layer is dried over sodium sulfate and concentrated in vacuo to afford (3-bromo-pyridin-4-yl)-methanol as a yellow oil. MS (ESI) m/z 189.9 (M+H)+
後処理
- customfollowed by removal of the solvent in vacuo
- dissolutionThe residue is redissolved in DCM
- washwashed with water twice
- dry with materialThe organic layer is dried over sodium sulfate
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-196e5af2399b48d5b099b41a5f155237
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09242963B2
反応ノート
読み込み中…